フコイダン療法をお考えなら統合医療と健康を考える会へ

特定非営利活動法人(NPO法人) 統合医療と健康を考える会

ご相お問い合わせは
統健会まで

0120-661-566

  • 受付時間:10:00~17:00
  • 定休日:土・日・祝休み
  • 受付時間10:00~17:00
  • 定休日 土・日・祝休み

研究と症例
研究と症例

Menu

 

世界インビトロ生物学国際会議

Anti-cancer Effect of Enzyme-digested Fucoidan Extract from Seaweed Mozuku.

Fucoidan is viscous fucose-rich polysaccharide derived from brown algae. Recently, the abalone enzyme-digested fucoidan extract derived from seaweed Mozuku of Clado-siphon novae-caledoniae kylin (fucoidan extract) draws much attention because of its clinical anti-cancer effect in Japan. The fucoidan extract suppressed the growth of mouse colon cancer cells in vivo. Here, we report the can-cer cell-specific apoptosis inducing effects of the fucoidan extract. The fucoidan extract suppressed the growth of various anchorage-dependent and independent cancer cells. The fucoidan extract contained low molecular weight components, which induced apoptosis of human leukemia HL60 cells but not of human lymphocytes, It has been known that sugar chain expression on the membrane surface of cancer cells changes dependent upon their malignancy. The analysis on sugar expression profiling using eight kinds of FTTC-labeled (Con A, DBA, LCA, PHA-E4, PNA, RCA120,UEA-I, WGA) revealed that the expression of Con A binding sugar chain was enhanced by the treatment of human lung adenocarcinoma A549, human uterine carcino-ma Hela, and human fibrosarcoma HT1080 cells with the fucoidan extract. Con A^induced apoptosis of cancer cells was stimulated in a dose-and time-dependent manner by the treatment with the fucoidan extract but not of human normal fibroblast TIG-1 cells.

※世界インビトロ生物学国際会議 にて掲載されました。
当会理事の白畑 實隆教授の研究結果です。

ページトップへ戻る